If you're playing OpenSP, make sure you're choosing one of the 9 OpenSP starting characters, not the default Normal Player one.
Most of the RB players did not report instability when playing, don't know why you or Spearhead has so many CTD's...on the test systems I ran every SP character up to level 35 with almost NO CTD, also played the whole SP campaign more than 10 times with very RARE CTD's....perhaps the mod it's not 100% foolproof, but ut should not behave as you describe it apparently does on you PC's...
If you want not to blow up in Carolina, take a ship with an armor above 9000 and some armor enhancement, also keep your nanos pool filled, and you'll pass the system with no big probs...land on Columbia Transit to replenish your nanobots if you need to...