Sat Aug 02, 2003 11:22 pm by freighter fighter
for those of you on the TLR team, i think we are helping them with this :
The GNRA hairpin is a small secondary structural unit of RNA that contains what some have called an "unusually stable" tetraloop region bridging the two strands that form this helical hairpin. We have previously characterized short-timescale loop dynamics and thermal unfolding of the hairpin and have since undertaking numerous related studies in silico including: unfolding at a biologically relevant temperature, direct folding, evaluation of the equilibrium thermodynamics of this RNA hairpin via replica exchange stochastic dynamics, and calculations of the folding probabilities for a small ensemble of structures (Pfold), which allow us to examine the transition state for the folding event.
This series of projects is now complete, and is the launching point for the new 340-385 series which uses much more sophisticated algorithms to maximize the accuracy obtained and to examine the role of water molecules and ions in the folding and unfolding processes.
or at least i am
"What? Another girl! Tell me my boy. *whispers* what have you been doing?" - Tobias