Try posting in the official forums on their site. Much of decent help and knowledge is there, since the developers alos read and post there. It could be very likely that there are already troubleshooting guides that suite for your problem, as I once had trouble, too, and their forums have helped me definitely.

One of the key things that's been causing MS3D to crash recently is newer video cards and their drivers. Try disabling your hardware acceleration and see if that'll help. I recently upgraded my video card, and the new one isn't supported by MS3D 1.7.2... but after disabling hardware acceleration, it works just fine, using its software renderer (which on my rig means that I don't really see any slowdown). It's annoying to have to disable hardware acceleration, but it only takes a few seconds to do so.