Start in Omega-5 system Cadiz Base, buy a load of Artifacts ($130).
Take the Cambridge jump hole and head for the New London jump gate (1 trade lane).
From there take the trade lane to New London.
Sell the artifacts on the planet for about $1300 per unit.
For the way back get Food rations or Oxygen, small profit there...
I personally managed to find Light arms from Planet Cambridge, that is on the way, for cheap and sold them to Omega-41 system, Leon Base for about $1000 unit profit, but now that im checking from the map, Cambridge doesnt have Light arms in the "selling" list...so might wanna check that for yourselfs.
Main thing to do with this trade route is that you are friendly or neutral with Corsairs or you will get blown to bits...
Also neutral with Bretonia authorities is good
Only ones i got attacked by was the Mollys, and that was always in New London, so no matter there cause i managed always to dock before they even shot me once...
So there you have it, i hope its good for someone.