Might want to make sure they have proper Zones if required. I know when an NPC gets near an object (like a jumphole) that isn't zoned properly it'll CTD. Try commenting out all your encounters in the system (if thats feasible, I have no idea lol).

Stefan how long have you been coming here, INFO bud, the more you give us the better we can help.
With objects the usual cause is a typo in the achetype or loadout nickname or in the loadout itself ie pointing at a non existant gun, powerplant or model. As long as you've got the names right you can add a really F@*&$? model and it won't CTD on you.
If it's a zone then a CTD only normally happens if you've forgotten or misspelled the "encounter parameter" for it, a bad ship or loadout can cause a crash but only when your within spawn range (about 4 to 5k iirc).

**shuffles of with a new headache**

It´s mainly bases and tredelanes. e.g. I put an order base or a tradelane in the top unknown system it crashes.